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本文报道了三种不同的酶诱导剂对烟草烟雾(TS)致突变代谢活性的影响,以及TS对小鼠外周血正染红细胞的致断裂作用和累积遗传毒性作用。微核实验用7～10周龄、15～18g雌性BDF小鼠,每组10只,按Balansky(1987)的方法,每天置于14L含有600ml TS的玻璃染毒容器中60或120、180分钟,染毒后24小时或42天后处死动物,制备骨髓涂片,每只动物计数1000个多染红细胞,并分别于染毒后24、48小时,7、14、42天取血按Barale等(1985)的方法制备外周血涂片,每只鼠计数
In this paper, we report the effects of three different enzyme inducing agents on the mutagenic metabolic activity of tobacco smoke (TS) and the effect of TS on the rupture and cumulative genotoxicity of mouse peripheral blood erythroblasts. Micronucleus experiments Seven to ten weeks old, 15 to 18 g female BDF mice, 10 in each group, were placed daily in 14 L glass-lighted containers containing 600 ml TS for 60 or 120, 180 minutes as described by Balansky (1987) The animals were sacrificed at 24 hours or 42 days after exposure to prepare a bone marrow smear. Each animal counted 1000 polychromatic erythrocytes and was taken at 24, 48 hours, 7,14, and 42 days after exposure, respectively. Barale et al. Peripheral blood smears were prepared by the method of 1985, counting per mouse