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对９４例婴儿应用酚妥拉明后出现鼻塞、呼吸困难加重等不良反应者１６例（男性９例，女性７例；年龄４±４ｍｏ），进行临床分析，发现酚妥拉明引起不良反应的原因除与该药药理性质有关外，可能与年龄（越小，越易发生），个体差异及用药途径（静脉推注比静脉滴注发生率略高）有关。故本品应用于小婴儿时，避免速度过快，浓度过高，出现严重鼻塞即停药。
Ninety-four infants were treated with phentolamine, followed by 16 cases (9 males and 7 females; age 4 ± 4 months) with nasal obstruction, dyspnea and other adverse reactions. The clinical analysis showed that phentolamine caused adverse reactions The reason may be related to the pharmacological properties of the drug, which may be related to the age (the smaller the more likely to occur), the individual differences and the route of administration (IV bolus injection rate slightly higher). Therefore, this product is used in small infants, to avoid excessive speed, high concentration, a serious nasal obstruction that is withdrawal.