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目的:探讨帕瑞昔布钠用于无痛人工流产术的临床效果及其安全性。方法:120例人工流产术患者随机分为帕瑞昔布钠组和芬太尼组,对比分析两组丙泊酚的用量、唤醒时间、术中生命体征、麻醉效果、不良反应的发生情况和术后VAS评分。结果:帕瑞昔布钠组丙泊酚用量及苏醒时间均短于芬太尼组,术中血流动力学变化较芬太尼组稳定,且不良反应的发生率和VAS评分也显著低于芬太尼组(P<0.05)。结论:帕瑞昔布钠可显著减少无痛人流术中丙泊酚的总用量,麻醉效果良好,且无明显不良反应,是一种可用于无痛人工流产术的安全、有效的药物。
Objective: To investigate the clinical effect and safety of parecoxib sodium in painless artificial abortion. Methods: One hundred and twenty cases of induced abortion were randomly divided into parecoxib group and fentanyl group. The propofol consumption, wake time, intraoperative vital signs, anesthesia effects and adverse reactions were compared between the two groups Postoperative VAS score. Results: The dosage and recovery time of propofol in the parecoxib group were shorter than those in the fentanyl group. The hemodynamic changes during the operation were more stable than those in the fentanyl group, and the incidence of adverse reactions and the VAS score were also significantly lower than those in the fentanyl group Fentanyl group (P <0.05). Conclusion: Parecoxib sodium can significantly reduce the total amount of propofol in painless abortion, with good anesthetic effect and no obvious adverse reactions. It is a safe and effective drug for painless artificial abortion.