Objective:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit(ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese rats.Methods:The high fat diet induced obese rals were orally treated with orlistat(50 mg/kg) and ELSF(100,200.300 mg/kg/day) to the respective treatment groups.The body weight,lasting blood glucose level,lipid profile, serum levels of tumor necrosis factor-α(TNF-α) in rats were measured after 30 days of treatment adn compared to the obese control animals.Results:ELSF significantly(P < 0.001) reduced the body weight gain,fasting blood glucose,total cholesterol,triglyceride,total protein and TNF-α.Conclusions:These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment. Objective: To investigate the effects of ethanolic extract of Lagenaria siceraria fruit (ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese rats. Methods: The high fat diet induced obese minerals were orally treated with orlistat (50 mg / kg) and ELSF (100,200.300 mg / kg / day) to the respective treatment groups. body weight, lasting blood glucose level, lipid profile, serum levels of tumor necrosis factor- days of treatment adn compared to the obese control animals.Results: ELSF significantly (P <0.001) reduced the body weight gain, fasting blood glucose, total cholesterol, triglyceride, total protein and TNF- siceraria has excellent pharmacological potential to prevent fat amassment.