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单克隆抗体癌胚抗原(CEA)是过去研究最多的肿瘤相关抗原(TAAs)之一。许多报道表明,CEA是一组同种抗原,抗 CEA 抗体对它有显著不同反应性。抗 CEA 单克隆抗体(McAb)能与 CEA 分子上各个表位发生反应,其中一些对结肠癌有高度反应性,并能与肿瘤表面结合。Koprowoski 等(1979年)报道了一种19-9的McAb,它能与一种组织碳水化合物抗原决定簇(CA19-9)发生反应。在正常胃和肠粘膜、胰、脾、红细胞、黑色素瘤细胞系的提取物中及人神经节苷脂内均未检出这种抗原。21例结直肠腺癌中的12例、5例胃肠腺癌中的
The monoclonal antibody carcinoembryonic antigen (CEA) is one of the most studied tumor-associated antigens (TAAs) in the past. Many reports indicate that CEA is a group of allogeneic antigens that are significantly differently reactive with anti-CEA antibodies. The anti-CEA monoclonal antibody (McAb) reacts with various epitopes on the CEA molecule, some of which are highly reactive to colon cancer and bind to the tumor surface. Koprowoski et al. (1979) reported a 19-9 McAb that reacts with a tissue carbohydrate antigenic determinant (CA19-9). No such antigens were detected in normal stomach and intestinal mucosa, pancreas, spleen, red blood cells, melanoma cell line extracts and human gangliosides. Twenty-one cases of colorectal adenocarcinoma in 21 cases and 5 cases of gastrointestinal adenocarcinoma