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目的探讨P38 MAPK在高血压脑出血外周血单个核细胞中的表达情况及其临床意义。方法选择宁夏医科大学总医院神经外科确诊的高血压脑出血患者50例作为实验组,在发病后1、3、7、14 d分别抽取静脉血,用PCR荧光检测法测定P38 MAPK mRNA的表达,同时ELISA检测外周血IL-6/8含量,与正常体检者(25例,对照组)对比,并分析表达意义。结果实验组患者外周血单个核细胞核内P38 MAPK mRNA表达和血清IL-6/8含量均高于正常体检者(P<0.05),病情越重,P38 MAPK mRNA及IL-6/8含量越高,在脑出血后3 d时P38 MAPK mRNA及IL-6/8含量达到高峰,此后表现为下降趋势,P38MAPK mRNA及IL-6/8含量之间呈正相关(P<0.05)。结论 P38 MAPK、IL-6、IL-8参与了高血压脑出血的炎症反应,与脑出血后脑组织损伤机制相关。
Objective To investigate the expression of P38 MAPK in peripheral blood mononuclear cells of hypertensive intracerebral hemorrhage and its clinical significance. Methods Fifty patients with hypertensive intracerebral hemorrhage diagnosed by Department of Neurosurgery, General Hospital of Ningxia Medical University were selected as the experimental group. Venous blood was drawn at 1, 3, 7 and 14 days after onset, and the expression of P38 MAPK mRNA was detected by PCR fluorescence detection. At the same time, the content of IL-6/8 in peripheral blood was detected by ELISA, compared with normal subjects (25 cases, control group), and the significance was analyzed. Results The expression of P38 MAPK mRNA and IL-6/8 in the nucleus of peripheral blood mononuclear cells in the experimental group were significantly higher than those in the normal subjects (P <0.05). The more severe the disease, the higher the content of P38 MAPK mRNA and IL-6/8 , P38 MAPK mRNA and IL-6/8 content peaked at 3 days after intracerebral hemorrhage, then decreased. P38MAPK mRNA and IL-6/8 content were positively correlated (P <0.05). Conclusion P38 MAPK, IL-6 and IL-8 are involved in the inflammatory reaction of hypertensive intracerebral hemorrhage, which is related to the mechanism of brain injury after intracerebral hemorrhage.