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目的为此地区进行宫颈癌的早期防控措施提供依据。方法对2014年居住在上海市闵行区的37 049例本市户籍女性高危型人乳头瘤病毒(HPV)筛查情况及随访结果进行分析,采用高通量测序技术进行HPV基因分型检测。结果总体感染率为11.71%,前5位HPV基因型别分别为HPV52(2.99%)、HPV16(1.87%)、HPV58(1.87%)、HPV68(1.07%)、HPV18(1.03%)。感染率最高的为<30岁年龄组(14.55%),感染率最低的为70~79岁年龄组(5.41%),各年龄组差异有统计学意义(P<0.05)。结论闵行区本市户籍妇女HPV感染具有明显的基因亚型和年龄分布异质性,提示该地HPV疫苗的研制应用和宫颈癌高危人群管理应考虑闵行区优势HPV亚型和年龄因素。
Objective To provide basis for early prevention and control of cervical cancer in this area. Methods A total of 37 049 women with high risk human papillomavirus (HPV) screening and follow-up results of women living in Minhang District of Shanghai in 2014 were analyzed. High-throughput sequencing was used to detect HPV genotypes. Results The overall infection rate was 11.71%. The top five HPV genotypes were HPV52 (2.99%), HPV16 (1.87%), HPV58 (1.87%), HPV68 (1.07%) and HPV18 (1.03%). The highest infection rate was in the 30-year-old group (14.55%) and the lowest infection rate was in the 70-79-year-old group (5.41%). There was significant difference among all age groups (P <0.05). Conclusion HPV infection of registered permanent residents in Minhang District has obvious heterogeneity of genotypes and age distributions, suggesting that the development and application of HPV vaccine and management of high risk population of cervical cancer in Minhang District should take into account the prevalence of HPV subtypes and age in Minhang District.