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目的探讨乙型肝炎患者血清学标记的表现模式,方法共2693份乙型肝炎病毒(HBV)血清检测标本均通过DG3022A型酶联免疫检测仪进行结果测试。结果本次血清病毒学标记模式可分为感染期模式组和恢复期模式组,两组共计20种模式。感染期模式组以“145”和“135”模式为主占总病例的62.9％;恢复期模式组以“2”和“24”模式为主,占总病例的13.7％。根据随访结果显示,模式改变大致分为5种类型。结论本次HBV血清学标记模式较复杂,除检测误差外,产生少见模式的主要原因为低滴度抗—HBc或低滴度抗—HBs等。推测HBV血清学标记模式转换顺序依次为e系统转换、s系统转换、抗—HBe消失或抗—HBe与抗—HBs消失等。
Objective To investigate the serological markers in hepatitis B patients. Methods A total of 2693 hepatitis B virus (HBV) serum samples were tested by DG3022A ELISA kit. Results The pattern of serum virological markers could be divided into infection mode group and convalescent mode group, with a total of 20 modes in both groups. In the infection mode group, “145” and “135” modes accounted for 62.9% of the total cases. The convalescent mode group was dominated by “2” and “24” modes, accounting for 13.7% of the total cases. According to follow-up results show that the pattern changes can be divided into five types. Conclusion The pattern of HBV serology is complicated. In addition to the detection error, the main reason for the rare pattern is low-titer anti-HBc or low-titer anti-HBs. It is speculated that HBV seroconversion pattern followed by e-system conversion, s-system conversion, anti-HBe disappearance or anti-HBe and anti-HBs disappear.