【摘 要】
：
In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (ACh
【机 构】
：
Department of Chemistry,School of Pharmacy,State Key Laboratory for Drug Research
论文部分内容阅读
In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (AChE) inhibition, two main ingredients, salvianolic acid B (1) and rosmarinic acid (2), which were isolated from S. Miltiorhiza water extract, were investigated in vitro by NMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have AChE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.
其他文献
采用高频脉冲电沉积法在不锈钢板上制备Ni-Co／SiC复合镀层。研究了镀液中SiC含量、脉冲频率、占空比以及平均电流密度对复合镀层中Si含量的影响，得到的较佳工艺参数为：纳米SiC8g
A new tetrastilbene named carasinol D (1) was isolated from the roots of Caragana sinica. Its structure was elucidated by spectroscopic analysis. Compound 1 was
An unexpected multi-component reaction of cyanothioacetamide with aldehyde and aminopyrazole under MWI was reported. Through this reaction, a series of pyrazolo
Let p denote a prime and P2 denote an almost prime with at most two prime factors. The author proves that for sufficiently large x,∑ρ≤хр+2＝P21 ＞1.13Cx/log2x,
Dynamic contact stiffness at the interface between a vibrating rigid sphere and a semi-infinite transversely isotropic viscoelastic solid is investigated. An os
Non-stationary time series could be divided into piecewise stationary stochastic signal. However, the number and locations of breakpoints, as well as the approx
This paper is concerned with the dynamic behaviors of wave propagation in layered periodic composites consisting of piezoelectric and piezomagnetic phases. The
The oxidation of 3-picoline to nicotinic acid took place efficiently in an ethanol solution with O2 as the oxidant under the catalysis of T(o-C1)PPMn at 40-150
Neodymium-based heterocyclic Schiff base complex was prepared and applied for the coordination polymerization of isoprene. This complex polymerized isoprene to
A so-called "split-bottom ring shear cell" leads to wide shear bands under slow, quasi-static deformation. Unlike normal cylindrical Couette shear cells or rheo