抗生素与病原菌是一个矛盾体的两个方面,两者在不停顿的争斗中不断地发展和进化。抗生素的出现与发展导致了不同病原菌的消长与更迭,如青霉素的问世极大地抑制了金黄色葡萄球菌的肆虐,但同时以铜绿假单胞菌为代表的革兰阴性菌感染率逐渐升高,并取代了金黄色葡萄球菌头号病原菌的位置;以第3代头孢菌素为代表的针对革兰阴性菌的新抗生素大量投入临床使用后,革兰阴性菌的感染率明显下 Antibiotics and pathogenic bacteria are two aspects of a contradictory body. Both of them develop and evolve constantly in a non-stop battle. The emergence and development of antibiotics led to the growth and development of different pathogens, such as the advent of penicillin greatly inhibited the raging of Staphylococcus aureus, but at the same time, Pseudomonas aeruginosa represented Gram-negative bacteria infection rate gradually increased, And replaced the number one pathogen of Staphylococcus aureus; the third generation of cephalosporins represented by the new gram-negative bacteria antibiotics put into clinical use, the infection rate of gram-negative bacteria significantly