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目的探讨小剂量阿司匹林联合硫酸镁治疗妊娠期高血压疾病(HDCP)患者对其血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平的影响。方法依循随机分配原则将200例HDIP患者分为对照组和观察组,前者单用硫酸镁药物治疗,后者于前者治疗基础上加服小剂量阿司匹林。比较两者治疗前后血清TNF-α、IL-6、IL-10水平变化情况及血黏度、血细胞压积、脐血流收缩期最大血流速度/舒张末期最小血流速度比值(S/D值)、脐动脉血流阻力指数(RI)值变化情况。结果药物治疗后,两组各项观察指标水平均存在一定幅度的变化,但观察组各项观察指标变化水平显著优于对照组,差异有统计学意义(P<0.05)。结论小剂量阿司匹林联合硫酸镁治疗,可调节患者炎性细胞分子紊乱状态,缓解临床不良体征和症状,疗效显著,具临床推广意义。
Objective To investigate the effect of low-dose aspirin combined with magnesium sulfate on the treatment of patients with gestational hypertension (HDCP) with high dose of aspirin combined with serum TNF-α, IL-6, IL-10 ) Level of influence. Methods According to the principle of random allocation, 200 patients with HDIP were divided into control group and observation group. The former was treated with magnesium sulfate alone and the latter plus aspirin with low dose. The changes of serum TNF-α, IL-6 and IL-10 levels before and after treatment were compared with those of blood viscosity, hematocrit, umbilical blood flow systolic maximum blood flow / end diastolic blood flow velocity ratio (S / D value ), Umbilical artery blood flow resistance index (RI) value changes. Results After the drug treatment, there were some changes in the levels of each observation group, but the changes of the observation group in the observation group were significantly better than those in the control group, the difference was statistically significant (P <0.05). Conclusion The combination of low-dose aspirin and magnesium sulfate can regulate the disorder of inflammatory cells and alleviate the clinical signs and symptoms of asthma, with significant curative effect and clinical significance.