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目的:探讨西宁地区阻塞性睡眠呼吸暂停综合征(OSAS)患者血浆高敏C-反应蛋白(hsCRP)和血液流变学的改变。方法:选取在我院经多导睡眠图确诊且未经治疗的OSAS患者59例为OSAS组,30例多导睡眠图(PSG)检查正常者为对照组,分别测定两组患者hsCRP水平及纤维蛋白原和血浆黏度的水平。结果:OSAS组与对照组相比血浆hsCRP水平(P<0.01)、纤维蛋白原(P<0.01)和血浆黏度(P<0.01)的水平增高。纤维蛋白原(r=0.776,P=0.01)、血浆黏度(r=0.702,P<0.01)、hsCRP(r=0.652,P<0.05)与呼吸紊乱指数(AHI)之间有相关性。结论:OSAS患者hsCRP、纤维蛋白原和血浆黏度的水平升高,且与OSAS严重程度有关。这些改变是心脑血管病危险因子之一。
Objective: To investigate the changes of plasma high-sensitivity C-reactive protein (hsCRP) and hemorheology in patients with obstructive sleep apnea syndrome (OSAS) in Xining. Methods: Fifty-nine patients with OSAS diagnosed by polysomnography in our hospital were enrolled as OSAS group and 30 normal subjects with polysomnography (PSG) as control group. The levels of hsCRP and fibrin Proteins and plasma viscosity levels. Results: Compared with the control group, the levels of plasma hsCRP (P <0.01), fibrinogen (P <0.01) and plasma viscosity (P <0.01) in OSAS group increased significantly. There were correlations between fibrinogen (r = 0.776, P = 0.01), plasma viscosity (r = 0.702, P <0.01) and hsCRP (r = 0.652, P <0.05) and respiratory disturbance index (AHI). CONCLUSIONS: The levels of hsCRP, fibrinogen and plasma viscosity in OSAS patients are elevated, and are related to the severity of OSAS. These changes are one of the risk factors for cardiovascular and cerebrovascular diseases.