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本文用232只小鼠进行4组实验。(1)灌服硝喹醋酸盐(N,570mg/kg×1)后分别肌注生理盐水(NS组)和叶酸(NF组,8mg/kg×1)。药后96h,NS组小肠绒毛显著减少、变短、上皮脱落、隐窝细胞退变,而NF组变化轻微。(2)硝喹能显著降低小肠DNA含量,随剂量增大和时间延长(至72h)而越明显。(3)分别伍用时酸及甲酰四氢叶酸钙后,与NS组比较,小肠DNA含量降低未见明显差异。(4)伍用叶酸后[~3H]TdR参入小肠DNA量比NS组增多。以上结果提示叶酸能加速DNA合成。从而有利于小肠粘膜上皮细胞的修复。
In this paper, 232 mice for 4 experiments. (1) After instillation of nitrate (570 mg / kg × 1), saline (NS group) and folic acid (NF group, 8 mg / kg × 1) were intramuscularly injected respectively. At 96h after drug treatment, the intestinal villi of NS group were significantly reduced, shortened, epithelial shedding, crypt cells degenerated, while NF group changed slightly. (2) Nitrate can significantly reduce the intestinal DNA content, with the dose increased and the time (up to 72h) and the more obvious. (3) Compared with the NS group, no significant difference was found in the DNA content of the small intestine after using the acid and leucovorin respectively. (4) Compared with NS group, [~ 3H] TdR incorporation into follicles increased with folic acid. The above results suggest that folic acid can accelerate DNA synthesis. Which is conducive to the repair of small intestinal epithelial cells.