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目的:评价红景天苷对实验性急性心梗大鼠心脏的疗效。方法:将大鼠随机分为单纯造模组、红景天苷低剂量组(50mg/kg)、红景天苷中剂量组(100mg/kg)及红景天苷高剂量组(200mg/kg),复方丹参滴丸组(70mg/kg),另选取10只健康大鼠为假手术组。造模前按不同剂量药物给予大鼠灌胃2周,采取结扎大鼠左冠状动脉前降支,造成大鼠急性心肌梗死模型,分别于造模前、造模后6小时及1周后观察肌钙蛋白T(c Tn-T),继续药物灌胃2周后处死大鼠,观察心肌梗死面积及心肌细胞。结果:(1)红景天苷治疗组大鼠各阶段c Tn-T水平显降低,红景天苷高剂量组下降最明显(P<0.05)。(2)红景天苷治疗组的心肌梗死面积减少及心肌纤维排列改善。结论:红景天苷可保护急性心梗的大鼠的心脏损伤。
Objective: To evaluate the effect of salidroside on the heart of experimental acute myocardial infarction rats. Methods: The rats were randomly divided into three groups: model group, salidroside low dose group (50mg / kg), salidroside middle dose group (100mg / kg) and salidroside high dose group ), Compound Danshen dripping group (70mg / kg), and another 10 healthy rats as sham operation group. Rats were given gavage with different doses of drugs for 2 weeks prior to model establishment. The left anterior descending coronary artery of rats was ligated to establish acute myocardial infarction model in rats. The rats were observed before model making, 6 hours and 1 week after modeling Troponin T (cTn-T), continue the drug 2 weeks after the rats were sacrificed to observe myocardial infarction area and myocardial cells. Results: (1) The levels of cTn-T in the salidroside treatment groups decreased significantly, and those in the salidroside high-dose groups decreased the most (P <0.05). (2) Salidroside treatment group myocardial infarction area reduction and myocardial fiber arrangement improved. Conclusion: Salidroside can protect the heart of rats with acute myocardial infarction.