磺胺类药物,由于长效磺胺的问世以及近年来磺胺增效剂(TMP)的临床应用,在细菌性疾患的治疗价值上仍占有一定的地位,并不因抗菌素品种不断增长而有被取代之势。积极组织生产疗效高、毒性低、剂量小、价格低的磺胺类药物仍然是我国医药工业的一个重大任务。4-磺胺-5,6-二甲氧基嘧啶是一种毒性低、疗效持久的磺胺药,其血液中有效浓度半衰期 Due to the advent of long-acting sulfonamide and the clinical application of sulfonamide synergist (TMP) in recent years, sulfonamides still occupy a certain place in the treatment value of bacterial diseases and are not replaced by the growing variety of antibiotics Potential. The active organization and production of high efficacy, low toxicity, small doses, low prices of sulfa drugs is still a major task of China’s pharmaceutical industry. 4-sulfanilide-5,6-dimethoxypyrimidine is a low toxicity, long lasting sulfa drugs, the effective concentration of blood half-life