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研究了人工海水、天然半咸水以及生理盐水对６种我国常用抗菌药物（环丙沙星、四环素、土霉素、氯霉 素、磺胺以及呋喃唑酮）体外抗两种鱼类病原细菌（Ａｅｒｏｍｏｎａｓ ｈｙｄｒｏｐｈｉｌａ和Ｖｉｂｒｉｏ ｆｌｕｖｉａｌｉｓ）活性的影响。结果表明：海水对几乎所有受试药物的抗菌活性均呈抑制作用，其中对土霉素的影响最为显著；半咸水可使土霉素、 四环素及磺胺药的抗菌活性下降；生理盐水对不同药物或不同细菌的作用不一致；呋喃唑酮的抗菌活性不受 ３种水质的影响。此外，喹诺酮与二价阳离子的螯合产物可能并不稳定，当用无二价阳离子水稀释后药物可 被重新释放。
The effects of artificial seawater, natural brackish water and physiological saline on the growth of six kinds of aeromonas hydrophila (Aeromonas hydrophila) in vitro against six kinds of commonly used antibiotics (ciprofloxacin, tetracycline, oxytetracycline, chloramphenicol, sulfonamides and furazolidone) And Vibrio fluvialis) activity. The results showed that seawater had an inhibitory effect on the antibacterial activity of almost all the tested drugs, of which oxytetracycline had the most significant effect. Brackish water decreased the antibacterial activity of oxytetracycline, tetracycline and sulfa drugs; The effect of drugs or different bacteria is inconsistent; the antibacterial activity of furazolidone is not affected by three kinds of water quality. In addition, the chelating products of quinolones with divalent cations may not be stable, and the drug may be released again after dilution with non-divalent cationic water.