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目的观察氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效。方法 80例急性脑梗死患者作为研究对象,随机分为观察组和对照组,各40例。对照组采用氯吡格雷进行治疗,观察组采用氯吡格雷联合前列地尔进行治疗。对比两组患者的临床疗效。结果治疗前,两组患者美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力评定量表(ADL)评分比较差异均无统计学意义(P>0.05);治疗后,两组NIHSS评分、ADL评分均优于治疗前,且观察组均优于对照组,差异均具有统计学意义(P<0.05)。观察组不良反应发生率5.00%低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论氯吡格雷联合前列地尔治疗急性脑梗死具有良好的临床疗效,能有效改善患者神经功能,提高患者生活质量,安全性较高,值得在临床推广应用。
Objective To observe the clinical effect of clopidogrel and alprostadil in the treatment of acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly divided into observation group and control group, 40 cases in each. The control group was treated with clopidogrel, and the observation group was treated with clopidogrel plus alprostadil. Compare the clinical efficacy of two groups of patients. Results Before treatment, there was no significant difference in NIHSS score and ADL score between the two groups (P> 0.05). After treatment, the NIHSS scores , ADL scores were better than before treatment, and the observation group were better than the control group, the differences were statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 5.00% lower than that in the control group (20.00%), the difference was statistically significant (P <0.05). Conclusion Clopidogrel combined with alprostadil for the treatment of acute cerebral infarction has good clinical curative effect, which can effectively improve the neurological function and improve the quality of life of patients with high safety, which is worthy of clinical application.