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神经元的存活在未梢神经损伤后功能恢复中起重要作用。颅内肿瘤或外伤病人可出现暂时或永久性面神经麻痹,尼莫地平做为一种L-型电压门控钙离子通道拮抗剂,在不同的中枢及周围神经系统损伤模型中,均证明具神经保护作用。本研究的目地在于评价颅内切断成年鼠面神经后,尼莫地平对其面神经核内运动神经元存活率的影响。 雄性Sprague-Dawley鼠37只,每只重量为200～250克。深度麻醉后行颞骨切开术,暴露面神经神经管及颅
The survival of neurons plays an important role in the functional recovery after the injury of the injured nerve. In patients with intracranial tumors or trauma, temporary or permanent facial paralysis may occur. Nimodipine is an L-type voltage-gated calcium channel antagonist and has been shown to be neuroprotective in various central and peripheral nervous system injury models Protective effects. The purpose of this study was to evaluate the effects of nimodipine on the survival rate of motor neurons in the facial nucleus after intracranial cutting off the facial nerve in adult rats. 37 male Sprague-Dawley rats, each weighing 200 to 250 grams. Temporal bone incision was performed after deep anesthesia to expose facial nerve and neural tube