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目的:探讨小剂量甲巯咪唑联合普萘洛尔治疗甲亢的临床效果。方法:选取2015年06月至2016年11月就诊于我院的甲状腺功能亢进症患者142例,采用随机分组原则分为单一组与联合组,每组各71例。单一组患者口服甲巯咪唑治疗,联合组患者在甲巯咪唑治疗的基础上加用普萘洛尔,共治疗8周。比较两组患者治疗前及治疗后8周后的甲状腺功能,包括TT3、TT4、FT3、FT4。结果:治疗8周后,两组患者的甲状腺功能指标均下降,且联合组患者的下降程度更显著,差异有统计学意义(P<0.05)。结论:小剂量甲巯咪唑联合普萘洛尔可有效的改善甲亢患者的甲状腺功能。
Objective: To investigate the clinical effect of low dose methimazole combined with propranolol in the treatment of hyperthyroidism. Methods: A total of 142 patients with hyperthyroidism admitted to our hospital from June 2015 to November 2016 were randomly divided into single group and combined group, with 71 cases in each group. A single group of patients treated with oral methimazole, combined group of patients treated with methimazole plus propranolol, a total of 8 weeks. Thyroid function, including TT3, TT4, FT3 and FT4, was compared between the two groups before treatment and after 8 weeks of treatment. Results: After 8 weeks of treatment, the thyroid function indexes decreased in both groups, and the decline degree in the combination group was more significant (P <0.05). Conclusion: A small dose of methimazole combined with propranolol can effectively improve thyroid function in patients with hyperthyroidism.