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目的观察复方苦参注射液联合化疗晚期大肠癌的疗效及不良反应。方法观察组采用奥沙利铂100 mg/m2,静脉滴注2 h,亚叶酸钙200 mg/m2静脉滴注2 h,随后氟尿嘧啶400 mg/m2静脉注射,氟尿嘧啶2.4~3.0 mg/m2持续静脉滴注46 h,复方苦参注射液15 ml,第1~10天用,2周重复;对照组奥沙利铂100 mg/m2,静脉滴注2 h,亚叶酸钙200 mg/m2静脉滴注2 h,随后氟尿嘧啶400 mg/m2静脉注射,氟尿嘧啶2.4~3.0 mg/m2持续静脉滴注46 h;4周期后评价疗效。结果观察组有效率较高,但与对照组相比差异无统计学意义,病变进展率有统计学意义(P<0.05),提示联合复方苦参注射液进行治疗可使患者的病情进展得到延缓,生存期得以延长。观察组不良反应明显减轻,两组相比差异有统计学意义。结论复方苦参注射液联合化疗治疗晚期大肠癌可使生存期得以延长,减轻不良反应,提高对化疗的耐受性,提高患者生活质量。
Objective To observe the curative effect and adverse reactions of compound Kushen injection combined with chemotherapy for advanced colorectal cancer. Methods The observation group was treated with Oxaliplatin 100 mg / m2 intravenously for 2 h and leucovorin 200 mg / m2 for 2 h followed by intravenous injection of fluorouracil 400 mg / m2 and continuous infusion of fluorouracil 2.4-3.0 mg / m2 Drip 46 h, Compound Kushen injection 15 ml, 1 to 10 days with 2 weeks repeated; control group oxaliplatin 100 mg / m2, intravenous drip 2 h, leucovorin 200 mg / m2 intravenous drip Note 2 h, followed by intravenous injection of fluorouracil 400 mg / m2, fluorouracil 2.4 ~ 3.0 mg / m2 continuous intravenous infusion of 46 h; 4 cycles after the evaluation of the effect. Results The observation group was more effective, but the difference was not statistically significant compared with the control group, the rate of pathological progress was statistically significant (P <0.05), suggesting that the combination of compound Kushen injection can make the patient’s progress was delayed , The survival period can be extended. Adverse reactions in the observation group were significantly reduced, the difference between the two groups was statistically significant. Conclusion Compound Kushen injection combined with chemotherapy for advanced colorectal cancer can prolong survival, reduce adverse reactions, improve the tolerance of chemotherapy, and improve the quality of life of patients.