论文部分内容阅读
为了解湖州市健康人群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)抗体水平状况,并制定防制策略,采用分层随机抽样方法,分7个年龄组,在湖州市的南浔区、长兴县和安吉县三个监测县采集健康人群血清,采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测A群、C群Nm抗体(IgG)含量,抗体含量≥2mg/L为阳性水平。在监测的635人中,A群流行性脑脊髓膜炎(流脑)抗体阳性率为81.89%(520/635),平均含量为6.31mg/L,C群流脑抗体阳性率为61.73%(392/635),平均含量为2.74mg/L,不同年龄组间抗体水平差异有统计学意义(P均<0.01)。A群、C群流脑抗体阳性率年龄分布均呈“单峰”分布,其中A群流脑以7~14岁组为最高,C群高峰则在3~4岁组。0~4岁年龄组A群、C群流脑抗体阳性率差异无统计学意义,5岁及以上年龄段抗体阳性率A群明显高于C群(P<0.01)。不同性别间以及城镇、农村人群间A群、C群流脑抗体阳性率差异均无统计学意义。湖州市C群流脑抗体水平较低,有发生疾病流行的血清学基础。建议使用A群C群流脑结合疫苗代替2岁以内接种的A群流脑多糖疫苗,并加强人群流脑带菌率监测和流动儿童流脑疫苗查漏补种工作。
To understand the status of Neisseria meningitidis (Nm) antibody in healthy population of Huzhou City and to develop a strategy of prevention and treatment, stratified random sampling method was used in seven age groups in Nanxun District, Changxing County, Huzhou City, The serums of healthy people were collected from three monitoring counties in Anji County. The content of Nm antibody (IgG) in group A and group C was detected by enzyme-linked immunosorbent assay (ELISA), and the antibody level was ≥2mg / L. Among 635 people monitored, the positive rate of epidemic encephalitis group A antibody was 81.89% (520/635), the average content was 6.31 mg / L, and the positive rate of C group meningococcal antibody was 61.73% ( 392/635) with an average content of 2.74 mg / L. There was significant difference in antibody levels among different age groups (all P <0.01). The age distribution of the positive rate of meningococcal antibody in group A and group C showed “unimodal” distribution, in which group A meningitis was the highest in group 7-14 and group C was in group 3-4. There was no significant difference in the positive rate of meningococcal antibody between group A and group C in age group 0 to 4 years. The positive rate of antibody A in group 5 and over was significantly higher than that in group C (P <0.01). There were no significant differences in the positive rates of meningococcal antibody between group A and group C in different sexes, towns and rural areas. Huzhou City Group C meningoencephalitis antibody levels are low, there is a prevalence of serological pathogenesis. It is recommended to use group A and group C meningitis combined vaccine instead of group A meningitis cerebrospinal fluid vaccine inoculated within 2 years of age, and to strengthen the population of meningitis carrier rate monitoring and floating children meningitis vaccine leak detection and replanting work.