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目的了解乳头状甲状腺癌患病的影响因素,为相应防治策略的制定提供科学依据。方法采用以医院为基础1∶2配对病例对照研究方法对2013年4月—2014年6月在福建省肿瘤医院收治的123例乳头状甲状腺癌患者及同期在该医院进行健康体检的246名体检人群进行问卷调查。结果病例组患者体质指数>25.0 kg/m2、被动吸烟1~2天/周、被动吸烟≥3天/周、染发1~2次/年、染发≥3次/年、食油炸食品>5次/周、食十字花科植物>5次/周、CT检查≥3次、压力大、一级亲属甲状腺癌患者1例、一级亲属甲状腺癌患者≥2例的比例分别为14.63%、54.47%、33.33%、62.60%、4.88%、28.46%、50.41%、12.20%、20.33%、9.76%、6.50%,均高于对照组体检人群的6.10%、46.34%、19.92%、42.28%、2.03%、15.85%、33.74%、5.69%、10.57%、1.63%、1.22%,病例组患者锻炼1~2次/周的比例为10.57%,低于对照组体检人群的21.54%,差异均有统计学意义(均P<0.05);多因素条件logistic回归分析结果显示,体质指数>25.0 kg/m2、被动吸烟≥1天/周、染发≥1次/年、CT检查≥3次、压力大、一级亲属甲状腺癌患者≥1例是乳头状甲状腺癌患病的危险因素,锻炼1~2次/周是乳头状甲状腺癌患病的保护因素。结论体质指数、被动吸烟、染发、CT检查、压力情况、一级亲属甲状腺癌患病情况、锻炼情况是乳头状甲状腺癌患病的主要影响因素。
Objective To understand the influencing factors of papillary thyroid carcinoma and provide a scientific basis for the development of corresponding prevention and treatment strategies. Methods A hospital-based 1: 2 matched case-control study was performed on 123 papillary thyroid cancer patients admitted to Fujian Cancer Hospital from April 2013 to June 2014 and 246 physical examinations at the same hospital during the same period People surveyed. Results In the case group, the body mass index> 25.0 kg / m2, passive smoking 1-2 days / week, passive smoking ≥3 days / week, hair dyeing 1-2 times / year, Times / week, food cruciferous plants> 5 times / week, CT examination ≥ 3 times, pressure, first-degree relatives thyroid cancer patients in 1 case, first-degree relatives thyroid cancer patients ≥ 2 cases were 14.63%, 54.47 %, 33.33%, 62.60%, 4.88%, 28.46%, 50.41%, 12.20%, 20.33%, 9.76% and 6.50% respectively, all of which were higher than those of the control group, which were 6.10%, 46.34%, 19.92%, 42.28% and 2.03 %, 15.85%, 33.74%, 5.69%, 10.57%, 1.63%, 1.22% respectively. The proportion of patients in the case group who exercised 1-2 times a week was 10.57%, which was lower than 21.54% of the control group The results of multivariate conditional logistic regression analysis showed that body mass index> 25.0 kg / m2, passive smoking ≥1 days / week, hair dyeing ≥1 times / year, CT examination ≥3 times, First-degree relatives of thyroid cancer patients ≥ 1 case is a risk factor for papillary thyroid cancer, exercise 1 or 2 times / week is a protective factor in papillary thyroid cancer. Conclusions Body mass index, passive smoking, hair coloring, CT examination, stress status, the prevalence of thyroid cancer in first-degree relatives and exercise status are the main influencing factors of papillary thyroid cancer.