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目的:采用人工心脏起搏的方法制备家兔急性心房颤动模型,分别探讨胺碘酮与氯沙坦对心房颤动导致心房重构的不同干预效果。方法:40只家兔随机分为0.9%氯化钠溶液组(对照组)、胺碘酮组、氯沙坦组、合用组,分别灌胃给药1周,以600次/min的频率起搏心房8 h,并分别于起搏前、起搏后0.5、1、2、4、6、8 h及停止起搏后10、20、30 min重复测定心房有效不应期(AERP)。结果:①经过8 h快速起搏后对照组AERP200(100.63±7.5)ms和AERP150(95.01±6.2)ms均较起搏前明显缩短(均P<0.01),AERP200较AERP150缩短更为明显(P<0.05),胺碘酮组、氯沙坦组及合用组快速起搏前后AERP无显著变化。②停止快速起搏后,对照组AERP逐渐恢复,AERP200和AERP150在10 min内基本恢复至起搏前的95.78%和96.76%,30 min内基本恢复至起搏前的99.07%和99.39%。结论:短期快速心房起搏可致心房电重构;胺碘酮和氯沙坦可以逆转心房电重构。
OBJECTIVE: To establish a rabbit model of acute atrial fibrillation by artificial heart pacing and investigate the effects of amiodarone and losartan on atrial fibrillation-induced atrial remodeling. Methods: Forty rabbits were randomly divided into 0.9% sodium chloride solution group (control group), amiodarone group, losartan group and combination group. The rabbits were intragastrically administered for one week and started at a frequency of 600 beats / min Atrial fibrillation was performed for 8 h. Atrial parenchymal refractory period (AERP) was measured before pacing, 0.5, 1, 2, 4, 6 and 8 h after pacing, and 10, 20 and 30 min after pacing were stopped. Results: ① After 8 h rapid pacing, AERP200 (100.63 ± 7.5) ms and AERP150 (95.01 ± 6.2) ms were significantly shortened (P <0.01) and AERP200 was shorter than AERP150 (P <0.05). AERP did not change before and after rapid pacing in amiodarone group, losartan group and combination group. ② After stopping fast pacing, AERP gradually recovered in control group. AERP200 and AERP150 basically recovered to 95.78% and 96.76% of pre-pacing within 10 minutes, and recovered to 99.07% and 99.39% of pre-pacing in 30 minutes. Conclusion: Short-term rapid atrial pacing can cause atrial electrical remodeling; amiodarone and losartan can reverse atrial electrical remodeling.