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目的探讨早发型母乳性黄疸与喂养方式及胃肠激素的关系。方法选择剖宫产新生儿136进行监测,将符合早发型母乳性黄疸诊断标准的38例新生儿进一步采集血液标本,通过放射免疫法测定胃动素(MOT)和胃泌素(GAS)水平。另随机抽取同期剖宫产出生的30例正常新生儿作为对照组,同法测定MOT和GAS,并记录两组相应的喂养方式。结果早发型母乳性黄疸组MOT、GAS的水平明显高于对照组,在统计学上有显著性差异;两组开奶时间、哺乳时间、哺乳频率等在统计学上均有显著性差异。结论新生儿早发型母乳性黄疸与胃肠激素MOT、GAS水平的降低密切相关,且与喂养方式密切相关。因此对新生儿应改进母乳喂养,严密监测黄疸的发生,及早干预。
Objective To explore the relationship between early onset breast milk jaundice and feeding mode and gastrointestinal hormones. Methods Thirty-eight newborn infants with cesarean section were enrolled in the study. Thirty-eight neonates with early-onset breast milk jaundice were recruited for blood collection and motilin (MOT) and gastrin (GAS) levels were measured by radioimmunoassay. In addition, 30 normal newborns born at the same period of cesarean section were randomly selected as the control group. MOT and GAS were determined in the same method and the corresponding feeding methods were recorded. Results The levels of MOT and GAS in early-onset breast-milk jaundice group were significantly higher than those in control group, with statistically significant differences. There were statistically significant differences between the two groups in milk-opening time, breast-feeding time and breast-feeding frequency. Conclusion Neonatal early-onset breast milk jaundice is closely related to the reduction of gastrointestinal hormone MOT and GAS, and is closely related to the feeding mode. Therefore, newborns should improve breastfeeding, closely monitor the occurrence of jaundice, early intervention.