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目的 评价珍黄胶囊治疗食管癌的抗癌增效作用和毒性。方法 1996年 8月至 1999年 4月 ,64例病理确诊的食管癌病人随机分为二组 :研究组 (放疗 +珍黄胶囊 ) ;对照组 (单纯放疗 ) ,两组病人采用同样放疗方法和剂量。结果 在放疗至 40GY时 ,研究组和对照组的抗肿瘤有效率分别为 46.9(15 /3 2 )和 2 0 % (6/3 0 ) (P <0 .0 5 )。放疗结束后一个月 ,研究组病人的完全缓解率 3 7.5 % (12 /3 2 ) ,高于对照组 2 0 % (6/3 0 ) (P <0 .0 5 )。结论 珍黄胶囊配合外照射可提高食管癌治疗的近期疗效
Objective To evaluate the anti-cancer synergism and toxicity of Zhenhuang Capsule in the treatment of esophageal cancer. Methods From August 1996 to April 1999, 64 patients with pathologically confirmed esophageal cancer were randomly divided into two groups: the study group (radiotherapy + Zhenhuang Capsule), and the control group (radiotherapy alone). The two groups of patients received the same radiotherapy and dose. Results After radiotherapy to 40GY, the anti-tumor efficacy rates of the study group and the control group were 46.9 (15/32) and 20% (6/30) respectively (P < 0.05). One month after the end of radiotherapy, the complete remission rate of the study group was 37.5 % (12/32), which was higher than that of the control group 20% (6/30) (P < 0.05). Conclusion Zhenhuang capsule combined with external irradiation can improve the short-term efficacy of esophageal cancer treatment