在临床治疗心律失常时,常遇到洋地黄与其它抗心律失常药物合用的情况。合理联用药物可增强治疗效果,减少副作用;不合理的联用则产生不良反应,甚至毒性作用相加,导致恶果。洋地黄与异搏定洋地黄与异搏定合用时,异搏定可通过减少地高辛的肾性和非肾性清除率,增加地高辛的血清浓度达70％。其增加程度与异搏 In the clinical treatment of arrhythmia, digitalis often encountered with other anti-arrhythmic drugs combined situation. Rational combination of drugs can enhance the treatment effect, reduce side effects; unreasonable combination adverse reactions, and even add up to toxic effects, leading to bad consequences. When digitalis and verapamil are combined with verapamil, verapamil increases the serum concentration of digoxin by 70% by reducing renal and non-renal clearance of digoxin. Its increased degree and different stroke