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第一个ACE抑制剂卡托普利(Captopril)降压效果显著,但作用时间较短。随后发展的依纳普利(Enalapril)克服了前述缺点,是一个有效的降压药。雷米普利(Ramipril)经动物实验证明比依纳普利起效更快,作用时间更长;健康人服药后1小时ACE活性开始下降,5mg能完全抑制ACE达8小时,残余效应长达8天;高血压患者口服本品后可见血压明显下降,持续24小时。 12例原发性高血压患者口服雷米普利首剂10mg,1小时后收缩压开始下降,5小
Captopril, the first ACE inhibitor, had a significant antihypertensive effect but had a shorter duration of action. Subsequent development of Enalapril overcomes the aforementioned drawbacks and is an effective antihypertensive drug. Ramipril has been proved to be more effective than enalapril by animal experiments and has a longer duration of action. ACE activity begins to decline 1 hour after taking the medicine in healthy people, 5 mg completely inhibits ACE for up to 8 hours and has a residual effect of up to 8 days; hypertensive patients after oral administration of this product showed a significant drop in blood pressure, sustained for 24 hours. 12 patients with essential hypertension oral ramipril first dose of 10mg, 1 hour after systolic blood pressure began to decline, 5 small