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目的探讨前蛋白转化酶枯草溶菌素9(PCSK9)水平与血脂等代谢相关指标的关系。方法采用随机抽样方法收集388名体检人员的空腹血样本388份,并对入选者进行问卷调查、体格检查及代谢相关指标的测定,用ELISA方法检测血清样本PCSK9水平。结果 PCSK9水平为(86.19±32.33)ng/ml,呈偏态分布,女性PCSK9水平显著高于男性(P<0.01)。PCSK9水平与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)呈正相关(P<0.05)。他汀类药物治疗组PCSK9水平显著高于未服用他汀类药物组(P<0.01)。结论人群中PCSK9水平呈偏态分布,并且与性别、TC、LDL-C、HDL-C有关。他汀类药物可以升高血PCSK9水平。
Objective To investigate the relationship between preprotein convertase subtilisin 9 (PCSK9) levels and other lipid-related metabolic parameters. Methods A total of 388 fasting blood samples from 388 medical staffs were collected by random sampling method. Questionnaires, physical examinations and metabolism related indexes of 388 medical staffs were collected. The level of PCSK9 in serum samples was detected by ELISA. Results The level of PCSK9 was (86.19 ± 32.33) ng / ml, showing a skewed distribution. The level of PCSK9 in women was significantly higher than that in men (P <0.01). The level of PCSK9 was positively correlated with TC, HDL-C and HDL-C (P <0.05). The level of PCSK9 in the statin group was significantly higher than that in the non-statin group (P <0.01). Conclusion The level of PCSK9 in the population is skewed, and is related to sex, TC, LDL-C and HDL-C. Statins increase blood PCSK9 levels.