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本文报道两例服用甲基多巴(methyldopa)和地高辛(digoxin)发生症状性窦性心动过缓患者。例1为74岁女性,患原发性高血压,71岁开始服甲基多巴1.5g/d。1年后因轻度心力衰竭服地高辛0.25mg/d。随后出现健忘,眩晕及头昏,曾因言语障碍及左半身轻瘫持续4小时而住院。当时心率45/min,后继用地高辛0.25mg/d,甲基多巴0.75g/d。3个月后动态心电图示持续窦性心动过缓,心率32～60(平均50)/min,血清地高辛浓度2.1ng/ml。停用地高辛10天、停用甲基多巴4天后电生理检查结果正常,颈动脉窦按摩未能引出显著窦性心动过缓。以后用地高辛0.25mg/d和盐酸肼苯哒嗪(hydralazine
This article reports two patients with symptomatic sinus bradycardia who took methyldopa and digoxin. Example 1 was a 74-year-old woman with essential hypertension and methyldopa 1.5 g / d at age 71. After 1 year due to mild heart failure taking digoxin 0.25mg / d. Followed by forgetfulness, dizziness and dizziness, was due to speech impairment and left half of paralysis for 4 hours and hospitalized. Heart rate was 45 / min, followed by digoxin 0.25mg / d, methyl dopa 0.75g / d. Three months later, Holter showed continuous sinus bradycardia with a heart rate of 32-60 (average 50) / min and serum digoxin concentration of 2.1 ng / ml. Disable digoxin for 10 days, 4 days after the withdrawal of methyldopa electrophysiological findings were normal, carotid sinus massage failed to lead to significant sinus bradycardia. After digoxin 0.25mg / d and hydralazine hydrochloride (hydralazine