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慢性心力衰竭(chronic heart failure,CHF)是大多数心血管疾病的最终归宿,因具有高发病率、高病死率而引起人们的关注。CHF的标志是左心室进行性扩张、左室壁压力的增加,导致心肌耗氧量增加。根据拉普拉斯定律,运用一种组织工程学技术增加室壁厚度、减少心室腔直径,从而减少室壁压力、改善左室功能,本文总结归纳了这种组织工程技术在治疗CHF中的作用机制和Algisyl-LVR相关的试验结果。
Chronic heart failure (CHF) is the ultimate fate of most cardiovascular diseases, which has aroused people’s attention because of its high morbidity and high mortality. The hallmark of CHF is the progressive dilation of the left ventricle and increased pressure in the left ventricle, leading to increased myocardial oxygen consumption. According to Laplace’s law, the use of a tissue engineering technique to increase wall thickness, reduce ventricular cavity diameter, thereby reducing wall pressure, improve left ventricular function, this paper summarizes the role of tissue engineering in the treatment of CHF Mechanism Algisyl-LVR-related test results.