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目的 :探讨益髓生血灵的疗效机制及中医肝、脾、肾在血液生成中的作用。方法 :建立乙酰苯肼小鼠溶血性贫血模型 ,观察小鼠体重、脏器重量及血RBC、Hb、HCT变化。结果 :益髓生血灵通过补肾、养肝、健脾共用 ,提高模型小鼠血RBC、Hb、HCT ,减轻肝、脾肿胀程度 ,阻止体重下降。复方组明显优于不同组分组 ,尤以复方中剂量为佳 ,而单纯补肾效果最差。结论 :益髓生血灵通过提高模型小鼠血RBC、Hb、HCT水平改善肝、脾肿胀程度和体重增长速度 ;中医肝、脾、肾在血液生成中发挥着重要作用
Objective: To explore the therapeutic mechanism of Yishuishengxueling and the role of liver, spleen and kidney in blood formation. Methods : To establish a hemolytic anemia model of acetophenone mouse, observe the change of body weight, organ weight and blood RBC, Hb, HCT. Results: Yishuishengxueling used kidney, liver and spleen to increase blood RBC, Hb, and HCT in model mice, reduce liver and spleen swelling and prevent weight loss. The compound group is obviously better than the different component groups, especially the compound medium dose is better, and the pure kidney effect is the worst. Conclusion : Yishuishengxuelin can improve liver and spleen swelling degree and body weight growth rate by increasing blood RBC, Hb and HCT levels in model mice; Chinese medicine liver, spleen and kidney play an important role in blood production.