关于鼻内应用人白细胞干扰素预防呼吸道感染的效果,近来已有所报道。最初是应用重组α2b干扰素(IFN-α2b)45×10~6IU/日进行预防,并用鼻病毒和冠状病毒进行攻击,在攻击前,如果给予足量αIFN(HuIFN-α),则可阻止上述病毒的感染,但如给药时间长,则会出现鼻内刺激症状。一般认为在志愿者中,企图以较少量的干扰素,达到既能有效地抗病毒感染,又无副作用可能是不行的。对自然感染者给予干扰素10×10~6IU/日,证 The effect of intranasal administration of human leukocyte interferon on the prevention of respiratory infections has recently been reported. Initially, 45 × 10 ~ 6 IU / day of recombinant α2b interferon (IFN-α2b) was used for prophylaxis and challenged with rhinovirus and coronavirus. A sufficient amount of αIFN (HuIFN-α) Virus infection, but if administered for a long time, there will be intranasal irritation. It is generally considered that among volunteers, it may not be feasible to attempt to achieve antiviral infection effectively with a smaller amount of interferon without side effects. Naturally infected with interferon given 10 × 10 ~ 6IU / day, card