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目的：模建人ＩＬ－６Ｒα的三维结构，为构建可拮抗ＩＬ－６作用的ＩＬ－６Ｒα的突变体提供理论依据。方法：以生长激素受体为模板蛋白，在Ｉｎｔｅｒｎｅｔ互联网络上利用Ｓｗｉｓ－Ｍｏｄｅｌ蛋白同源结构模建工具进行ＩＬ－６Ｒα配基结合区的三维结构模建。结果与结论：得到了人ＩＬ－６Ｒα配基结合区的三维结构，并对模型进行了评价，确定了ＩＬ－６Ｒα上与异六聚体复合物一致的作用界面，为构建ＩＬ－６Ｒα的突变体提供了理论依据，并提示双突变体Ｃ２７７Ｄ／Ｈ２８０Ｉ可能既与ＩＬ－６具有高亲和力，又可拮抗ＩＬ－６的作用
OBJECTIVE: To construct a three-dimensional structure of human IL-6Rα and provide a theoretical basis for constructing a mutant of IL-6Rα that can antagonize the action of IL-6. METHODS: The three-dimensional structure of IL-6Rα ligand-binding domain was constructed by using the growth hormone receptor as a template protein on the internet through Swis-Model homology modeling tool. RESULTS AND CONCLUSION: The three-dimensional structure of the human IL-6Rα ligand binding region was obtained and the model was evaluated to determine the consistent interface of IL-6Rα with the hexameric complex for the construction of a mutation in IL-6Rα Provide a theoretical basis and suggest that the double mutant C277D / H280I may both have high affinity with IL-6 and antagonize IL-6