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目的观察特米沙坦对高血压病(EH)病人的疗效及内皮血管活性物质内皮素1(ET-1)、一氧化氮(NO)、降钙素基因相关肽(CGRP)和血管紧张素Ⅱ(AngⅡ)的影响。方法对96例EH病人用特米沙坦治疗8周,观察用药前后血ET、NO、CGRP和AngⅡ的变化。结果特米沙坦治疗EH总有效率为91·7%。特米沙坦治疗后血NO、CGRP浓度均较治疗前显著升高(P<0·01),血ET浓度显著下降(P<0·01),AngⅡ水平也升高(P<0·01)。结论特米沙坦有较好的降压作用,可明显改善EH病人血管内皮功能。
Objective To observe the effects of telmisartan on patients with essential hypertension (EH) and the effects of endothelin (ET-1), nitric oxide (NO), calcitonin gene related peptide (CGRP) and angiotensin Ⅱ (Ang Ⅱ) influence. Methods Ninety-six patients with EH were treated with telmisartan for 8 weeks. The changes of ET, NO, CGRP and AngⅡ were observed before and after treatment. Results The total effective rate of treatment with Ethausartan was 91.7%. The concentrations of NO and CGRP in blood were significantly higher than those before treatment (P <0.01), the concentration of ET in blood was significantly decreased (P <0.01) and the level of AngⅡ was also increased (P <0.01 ). Conclusion Dexartan has better antihypertensive effect, can significantly improve endothelial function in patients with EH.