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建立一个稳定可靠的实验模型对研究帕金森病(PD)的发病和治疗是尤其必要的。自从发现1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)能在人类诱发PD以来,人们对其神经毒性作了大量研究。MPTP及其有效成分1-甲基-4-苯基吡啶离子(MPP+)对中脑黑质多巴胺能神经元有选择性的破坏作用,从而发挥其诱导PD的毒性作用。在过去的几十年里对MPTP/MPP+诱导的PD实验模型的研究取得了显著的进展,目前MPTP/MPP+诱导的PD实验模型已广泛地用于PD研究。
The establishment of a stable and reliable experimental model is particularly necessary for the study of the pathogenesis and treatment of Parkinson’s disease (PD). Since it was found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can induce PD in humans, a great deal of its neurotoxicity has been investigated. MPTP and its active ingredient 1-methyl-4-phenylpyridinium ion (MPP +) can selectively detoxify dopaminergic neurons in the substantia nigra and exert their toxic effects on PD. In the past few decades, significant progress has been made in the study of MPTP / MPP + -induced PD experimental models. At present, MPTP / MPP + -induced PD experimental models have been widely used in PD research.