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目的观察黄体酮、多巴胺与速尿联合治疗肝硬化顽固性腹水患者中的疗效。方法我院就诊的肝硬化顽固性腹水患者42例,42例均采用自身对照方法,在常规利尿法无效后,再用低分子右旋糖酐250ml+多巴胺40mg和速尿60mg静脉滴注[按多巴胺5μg/(kg.min)],1次/d,并加黄体酮40～60mg/d,一次肌内注射。结果平均24h尿量较本法治疗前增加1000～1500ml,平均腹围缩小至70.2cm,腹水消失明显,且不会引起不可逆的电解质和肾功能改变。结论本方法无明显副作用,亦不受更多条件限制,患者易于接受,不失为一种有效的对症治疗方法。
Objective To observe the efficacy of progesterone, dopamine and furosemide in the treatment of patients with cirrhosis and refractory ascites. Methods Forty-two patients with cirrhosis and refractory ascites were treated in our hospital. 42 patients were treated with self-control method. After conventional diuretic therapy was invalid, low molecular dextran 250mg + dopamine 40mg and furosemide 60mg were given intravenously [5μg / ( kg.min)], 1 time / d, plus progesterone 40 ~ 60mg / d, once intramuscular injection. Results The average 24h urine output increased 1000 ~ 1500ml before treatment, the average abdominal circumference narrowed to 70.2cm, ascites disappeared significantly, and will not cause irreversible electrolyte and renal function changes. Conclusion This method has no obvious side effects, is not subject to more conditions, patients are easy to accept, after all, an effective symptomatic treatment.