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微小RNA-129(microRNA-129,miR-129)是一种能产生miR-129-5p、miR-129-1-3p和miR-129-2-3p等3种成熟产物的miRNA,它们在细胞生长、发育、癌变等生命过程中有重要作用.miR-129在多种常见肿瘤中呈现高表达(如:胃癌和肺癌)或低表达(如:乳腺癌和食管鳞状细胞癌)的多样现象,而且这种异常表达与肿瘤的发生发展有密切联系.miR-129通过作用于性别决定区Y框蛋白4(sex-determining region Y-box 4,SOX4)、细胞周期蛋白依赖激酶6(cyclin-dependent kinase6,Cdk6)、含缬酪肽蛋白(valosin containing protein,VCP)和磷脂酰肌醇蛋白聚糖-3(glypican-3,GP3)等多种靶基因而在肿瘤发生、发展过程中起着重要作用.
MicroRNA-129 (miRNA-129, miR-129) is a miRNA that can generate three mature products of miR-129-5p, miR-129-1-3p and miR-129-2-3p, Growth, development, cancer, etc. MiR-129 has multiple phenomena such as high expression (such as gastric cancer and lung cancer) or low expression (such as breast cancer and esophageal squamous cell carcinoma) in a variety of common tumors , And this aberrant expression is closely related to tumorigenesis and progression.miR-129, through its role in sex-determining region Y-box 4 (SOX4), cyclin- dependent kinase6 and Cdk6, valsin containing protein (VCP) and glypican-3 (GP3) and other target genes in the process of tumorigenesis and development Important role.