新生儿缺氧缺血性脑病(HIE)是围产期最常见的中枢神经系统病变.不仅严重威胁新生儿生命,而且是新生儿期后形成永久性神经损害最常见的病因之一,直接影响优生优育.目前对该病的治疗一般均为对症及支持疗法,但预后并不好,中重度新生儿HIE约有4.7～57%发生脑性瘫痪或智力低下等神经系统后遗症.我们自1991～1992年试用地塞米松联合胞二磷胆碱辅助治疗新生儿HIE,取得满意疗效,报告如下.1 临床资料1.1 一般资料 62例全部为住院患儿,孕龄均>38周,入院为生后1～120小时,平均16小时,24小时内入院者44例(70.9%).男47例,女15例.出生后Apgar评分47例,出生1分钟评分<3分,5分钟<6分43例(91.5%).有合并症40例(64.5%),其中以吸入 Neonatal hypoxic-ischemic encephalopathy (HIE) is the most common central nervous system disease perinatal period, not only a serious threat to neonatal life, but also one of the most common causes of permanent neurological damage after neonatal period, a direct impact At present, the treatment of the disease are generally symptomatic and supportive therapy, but the prognosis is not good, moderate to severe neonatal HIE about 4.7 to 57% of cerebral neuropsychiatric complications such as cerebral palsy or mental retardation and so on. We since 1991 ~ 1992 dexamethasone combined with citicoline adjuvant treatment of neonatal HIE, and achieved satisfactory results, the report is as follows.1 Clinical data 1.1 General information 62 cases of all hospitalized children, gestational age were> 38 weeks after admission for living 1 to 120 hours, an average of 16 hours, 44 patients admitted within 24 hours (70.9%), 47 males and 15 females.The Apgar score at birth 47 cases, birth 1 minute score <3 minutes, 5 minutes <6 minutes 43 Cases (91.5%). Complications of 40 cases (64.5%), which inhaled