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目的分析不同他汀类药物治疗早发冠心病急性心肌梗死患者的近期临床效果。方法选择2014年1月—2015年1月收治的急性心肌梗死患者76例作为研究对象,随机分为参照组和研究组各38例。参照组使用阿托伐他汀治疗,1片/次,1次/d;研究组使用瑞舒伐他汀治疗,1片/次,1次/d。两组均治疗7个月。记录并比较两组血流介导性舒张功能(flow-mediated dilatation,FMD)、hs-CRP、左室射血分数(left ventricular ejection fraction,LVEF)及血脂(LDL-C、TG、TC)水平。计量资料采用t检验,P<0.05为差异有统计学意义。结果治疗后,参照组LDL-C、TC、hs-CRP水平分别为(1.88±0.58)、(3.42±0.69)mmol/L、(2.39±0.70)mg/L,研究组分别为(1.46±0.30)、(3.01±0.70)mmol/L、(1.84±0.60)mg/L,两组比较差异均有统计学意义(均P<0.05)。结论治疗后,阿托伐他汀与瑞舒伐他汀治疗早发冠心病急性心肌梗死均有显著效果,但瑞舒伐他汀调节血脂效果更好,值得临床推广应用。
Objective To analyze the short-term clinical effects of different statins in the treatment of patients with acute myocardial infarction with premature coronary heart disease. Methods A total of 76 acute myocardial infarction patients admitted from January 2014 to January 2015 were selected as study subjects and randomly divided into reference group and study group of 38 cases. The reference group was treated with atorvastatin, 1 tablet / time, once / d; the study group was treated with rosuvastatin, 1 tablet / time, once a day. Both groups were treated for 7 months. The levels of flow-mediated dilatation (FMD), hs-CRP, left ventricular ejection fraction (LVEF) and serum lipids (LDL-C, TG, TC) were recorded and compared . Measurement data using t test, P <0.05 for the difference was statistically significant. Results After treatment, the levels of LDL-C, TC and hs-CRP in the reference group were (1.88 ± 0.58) and (3.42 ± 0.69) mmol / L and ), (3.01 ± 0.70) mmol / L and (1.84 ± 0.60) mg / L, respectively. There was significant difference between the two groups (all P <0.05). Conclusion After treatment, atorvastatin and rosuvastatin have a significant effect on the treatment of acute myocardial infarction with premature coronary heart disease. However, rosuvastatin is more effective in regulating blood lipid and is worthy of clinical application.