类固醇在现代医学中应用范围广、服药剂量大,常伴有一些使用并发症,其中消化性溃疡穿孔虽经广泛研究,但仍了解不够。本文回顾地分析了十年中(1974～1984)151例消化性溃疡穿孔病人,其中25例(17%)在发生穿孔前一周内曾使用过类固醇。作者试图说明:(1)与类固醇应用有关的穿孔发生率,(2)临床表现及预后;(3)发生穿孔病人应用类固醇的方式等问题。 Steroids in a wide range of modern medical applications, taking a large dose, often accompanied by the use of some complications, including peptic ulcer though widely studied, but still not enough understanding. This retrospective analysis of 151 patients with peptic ulcer perforation over a decade (1974-1984), of which 25 (17%) used steroids within a week prior to perforation. The authors sought to demonstrate: (1) the incidence of perforation associated with steroid use, (2) clinical presentation and prognosis, and (3) the manner in which steroid use occurs in perforation patients.