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目的:探讨限制性液体复苏孕兔失血性休克对肠道细菌移位的影响。方法:建立孕兔失血性休克模型,对比研究不同液体复苏孕兔失血性休克时,休克各时期的失血量、输液输血量,同时比较肝和回肠系膜淋巴结的细菌移位及血液内毒素的变化。结果:(1)休克各期限制性输液组输液输血量及失血量均少于传统输液组,两组差异有显著的统计学意义(P<0.01);(2)比较各组肝和回肠系膜淋巴结菌落数及血浆内毒素,限制性输液组明显低于其它各组,组间相互比较,差异有显著的统计学意义(P<0.01);(3)外周血培养结果显示限制性输液组阳性最低,组间差异有显著的统计学意义(P<0.01)。结论:限制性输液复苏孕兔失血性休克能更好地保护肠黏膜屏障,减少细菌移位,有效地防止休克发展,不失为抢救孕产妇失血性休克较为理想的输液方法。
Objective: To investigate the effect of restrictive fluid resuscitation in hemorrhagic shock in rabbits on intestinal bacterial translocation. Methods: The model of hemorrhagic shock in pregnant rabbits was established. The hemorrhagic shock and blood transfusion in different periods of resuscitation in rabbits with different fluid resuscitation were compared. The bacterial translocation and endotoxin in the liver and mesentery lymph nodes were also compared . Results: (1) The blood transfusion volume and blood loss in restricted infusion group were less than those in traditional infusion group at each stage of shock. The difference between the two groups was statistically significant (P <0.01). (2) (P <0.01). (3) Peripheral blood culture results showed that the positive rate in the limited infusion group was significantly higher than that in the limited infusion group The difference between the two groups was statistically significant (P <0.01). Conclusion: Resuscitative hemorrhagic shock with transfusion in pregnant rabbits can better protect the intestinal mucosal barrier, reduce bacterial translocation and prevent the development of shock effectively, which is an ideal infusion method for rescue of hemorrhagic shock in pregnant women.