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目的 观察眼内不同部位移植视网膜神经上皮层后诱发的免疫排斥 /赦免反应。方法 将新生小鼠视网膜神经上皮层分离后移植到受鼠眼结膜下、玻璃体腔和视网膜下间隙 ,术后 2、6、12、18、35 d用光镜观察移植物的存活 /排斥情况。结果 位于结膜下移植物 2 d内发生排斥反应 ,而位于玻璃体腔和视网膜下间隙的移植物不仅未被排斥 ,而且能进一步生长发育。结论 玻璃体腔和视网膜下间隙是免疫赦免区
Objective To observe the immunological rejection / pardon response induced by transplanted retinal nerve epithelium in different parts of the eye. Methods The neonatal mouse retinal neuroepithelial cortex was transplanted into the subconjunctival, vitreous and subretinal spaces of mice eyes. The survival and rejection of the implants were observed with light microscope at 2, 6, 12, 18 and 35 days after operation. As a result, the subconjunctival graft occurred rejection within 2 days, while the grafts located in the vitreous cavity and subretinal space were not only not rejected, but also grew further. Conclusion The vitreous cavity and the subretinal space are immunological forgiveness