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目的:观察消白胶囊灌胃给药后小鼠的急性毒性反应。方法:小鼠随机分为2组,给药组和空白对照组,给药组灌胃给药,3次/d,观察并记录小鼠口服消白胶囊的急性毒性反应,并计算半数致死量和最大给药量。结果:消白胶囊每日的最大给药剂量为141.6 g·kg-1(相当于临床拟用量的211.3倍),该剂量下小鼠未见明显毒性反应,14 d内动物无1例死亡,解剖后未见对脏器的毒性改变。结论:消白胶囊灌胃给药对小鼠急性毒性甚低,表明该药安全可靠。
Objective: To observe the acute toxicity of mice after oral administration of Xiao Bai Capsule. Methods: The mice were randomly divided into two groups: the administration group and the blank control group. The administration group was orally administered 3 times per day, and the acute toxicity of the mice was observed and recorded. The half lethal dose And the maximum dose. Results: The maximum daily dosage of Xiaobai Capsule was 141.6 g · kg-1 (equivalent to 211.3 times of clinical dosage). No obvious toxic reaction was observed in this dose. No animal died within 14 days, No anatomical changes in organ toxicity. Conclusion: Xiao Bai capsule intragastric administration of acute toxicity in mice is very low, indicating that the drug is safe and reliable.