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目的:探讨研究贵州省历年新生儿先天性苯丙酮尿症和甲状腺功能低下筛查情况,并提出相应对策。方法:选取2007年6月～2009年10月的新生儿的先天性苯丙酮尿症和甲状腺功能低下筛查资料为研究对象,其中2007年6月～2008年3月的9522名为A组,2008年4月～2008年12月的41152名为B组,2009年1月～2009年10月的121451名为C组,后将所有新生儿先天性苯丙酮尿症和甲状腺功能低下可疑阳性率、可疑阳性召回率、确诊率、随访率、治疗率及新生儿父母相关知识知晓情况进行统计学及比较。结果:经研究比较,随着年份的增加,可疑阳性率、确诊率降低趋势,可疑阳性召回率、随访率、治疗率呈现升高趋势,而新生儿父母相关知识知晓优良率也呈现上升趋势,经比较,P值均<0.05,均有统计学差异。结论:通过加强各项措施及随着年份的增加贵州省历年新生儿先天性苯丙酮尿症和甲状腺功能低下筛查情况呈现较好的发展趋势,值得进一步研究。
Objective: To study the status of congenital phenylketonuria and thyroid hypothyroidism in newborns in Guizhou Province and to put forward corresponding countermeasures. Methods: The screening data of congenital phenylketonuria and hypothyroidism in newborns from June 2007 to October 2009 were selected as the research object, of which 9522 from June 2007 to March 2008 were group A, 41152 from April 2008 to December 2008 were Group B, 121,451 from January 2009 to October 2009 were Group C, and all newborns with congenital phenylketonuria and suspected hypothyroidism positive rate , The suspicious positive recall rate, the diagnosis rate, the follow-up rate, the treatment rate and the related knowledge of the parents of newborns were statistically compared. Results: After years of research, the positive rate of suspicious patients, the rate of definite diagnosis decreased, the rate of suspicious positive recall, the follow-up rate and the treatment rate showed an upward trend, while the rate of awareness of newborn’s parents’ knowledge was also on the rise. After comparison, P values were <0.05, all with statistical difference. Conclusion: By strengthening the measures and with the increase of years, the screening trend of congenital phenylketonuria and hypothyroidism in newborns in Guizhou Province shows a good trend of development and deserves further study.