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目的:通过不翻转小肠囊法研究药物浓度、能量以及小肠上皮组织的P-蛋白对三七皂苷R1吸收的影响。方法:在小肠囊中加入不同浓度的三七皂苷R1溶液,比较不同浓度的三七皂苷R1的吸收差异;加入代谢抑制剂2-硝基酚,观察三七皂苷R1的吸收是否需要能量;观察P-蛋白抑制剂维拉帕米对三七皂苷R1吸收的影响。结果:三七皂苷R1的吸收与浓度呈线性,且需要能量。维拉帕米对三七皂苷R1的吸收无显著影响。结论:三七皂苷R1在大鼠肠道内的吸收有被动扩散性,三七皂苷R1可能不是P-蛋白的底物。
OBJECTIVE: To study the effects of drug concentration, energy and P-protein in small intestine epithelium on the absorption of notoginsenoside R1 by not turning the small intestine sac. Methods: Different concentrations of notoginsenoside R1 solution were added into the small intestine sac to compare the absorption differences of notoginsenoside R1. The metabolite inhibitor 2-nitrophenol was added to observe whether the absorption of notoginsenoside R1 required energy. Effect of p-protein inhibitor verapamil on the absorption of notoginsenoside R1. RESULTS: The absorption and concentration of notoginsenoside R1 were linear and required energy. Verapamil had no significant effect on the absorption of notoginsenoside R1. Conclusion: The absorption of notoginsenoside R1 in the intestinal tract of rats has passive diffusivity. Notoginsenoside R1 may not be the substrate of P-protein.