论文部分内容阅读
目的比较洛汀新对不同血压模式原发性高血压患者自主神经功能的干预效应,并探讨其原理。方法60例原发性高血压患者按照24小时动态血压监测结果分为杓型组(n=32)与非杓型组(n=28),在停用所有降压药及对HRV有影响的药物2周后应用洛汀新治疗6周,记录与比较两组治疗前后心率变异性时域分析指标。结果治疗6周后两组心率变异性时域分析指标均较治疗前增大,差异有统计学意义,P<0.01;且杓型组各项指标增幅均大于非杓型组,P<0.05。结论洛汀新可以改善不同血压模式高血压患者的自主神经功能;且其效果对杓型高血压患者要优于对非杓型高血压患者,主要原因是后者自主神经的损害和功能障碍要重于前者。
Objective To compare the interventional effects of Lotensin on autonomic nervous system in patients with essential hypertension with different blood pressure patterns and to explore its principle. Methods Sixty patients with essential hypertension were divided into dipper group (n = 32) and non-dipper group (n = 28) according to the results of 24-hour ambulatory blood pressure monitoring. After stopping all antihypertensive drugs and influencing HRV After 2 weeks of treatment with Lotensin, the drugs were treated for 6 weeks. The time-domain analysis of heart rate variability before and after treatment was recorded and compared. Results After 6 weeks of treatment, the indexes of heart rate variability in both groups increased more than those before treatment, the difference was statistically significant (P <0.01). The indexes of dipper group increased more than those of non-dipper group (P <0.05). Conclusion Lotensin can improve the autonomic nervous function of patients with hypertension in different blood pressure modes; and its effect is superior to that of non-dipper hypertensive patients in patients with dipping-type hypertension, mainly due to the damage and dysfunction of autonomic nervous system in the latter Heavier than the former.