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密度感应(Quorum sensing,QS)系统在细菌中普遍存在,细菌细胞通过识别和密度依赖性应答其自身或周围环境中其他菌细胞分泌的一种或多种信号分子来影响一系列基因的转录表达,从而参与细菌多种生理功能的调节。革兰阴性菌的密度感应现象最早发现于海洋弧菌中,本文主要综述了烈性肠道传染病病原体-霍乱弧菌中密度感应系统的研究进展,包括系统组成、信号传递过程、调节的生理功能及与其他全局性调控因子的相互作用。
Quorum sensing (QS) systems are ubiquitous in bacteria and bacterial cells influence the transcriptional expression of a range of genes by recognizing and density-dependent repression of one or more signaling molecules secreted by themselves or in the surrounding other bacterial cells , Thus participating in the regulation of many physiological functions of bacteria. The density-sensing phenomenon of Gram-negative bacteria was first found in Vibrio vulnificus. This article mainly reviewed the research progress of the density-sensing system of Vibrio cholerae, a pathogen of potent intestinal infectious disease, including system composition, signal transduction process, regulated physiological function And interactions with other global regulators.