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目的探讨阿维A辅助治疗复发性尖锐湿疣临床效果及安全性。方法选取本院近年来收治复发性尖锐湿疣患者70例,随机分为对照组和阿维A组,每组各35例;其中对照组采用常规对症治疗;阿维A组在对照组治疗基础上,加用阿维A口服治疗;比较两组患者临床复发率,治疗前后血清细胞因子水平及不良反应发生率等。结果阿维A组患者治疗后1个月、3个月及6个月临床复发率均显著低于对照组(P<0.05);对照组和阿维A组患者治疗后IL-4、IL-10及IFN-γ等细胞因子水平均显著优于治疗前,且阿维A组患者细胞因子水平改善程度均显著优于于对照组(P<0.05);阿维A组患者皮肤不适及口干发生率均显著高于对照组,但皮肤溃烂发生率显著低于对照组(P<0.05)。结论阿维A辅助治疗复发性尖锐湿疣可有效降低临床复发风险,改善机体细胞因子水平,提高机体免疫力,且无严重不良反应。
Objective To investigate the clinical effect and safety of Avi A in the treatment of recurrent condyloma acuminatum. Methods Seventy patients with recurrent condyloma acuminatum who were admitted to our hospital in recent years were randomly divided into control group and Avia A group with 35 cases in each group. Conventional symptomatic treatment was given in the control group. On the basis of the treatment in the control group, , Plus Avian A oral treatment; comparison of clinical recurrence rate of two groups of patients before and after treatment serum cytokine levels and the incidence of adverse reactions. Results The clinical relapse rates at 1 month, 3 months and 6 months after treatment were significantly lower in the Avi A group than those in the control group (P <0.05). After treatment, the levels of IL-4 and IL- 10 and IFN-γ and other cytokines levels were significantly better than before treatment, and the level of cytokine levels in patients with Avi A group were significantly better than the control group (P <0.05); A Wei A group of patients with skin discomfort and dry mouth The incidence was significantly higher than the control group, but the incidence of skin ulcers was significantly lower than the control group (P <0.05). Conclusions Avi A adjuvant treatment of recurrent condyloma acuminatum can effectively reduce the risk of clinical relapse, improve the level of cytokines in the body and improve the immunity of the body without serious adverse reactions.