作者依据临床资料列举了黄连和黄连素的不良反应:①急性心源性脑缺血综合征:用黄连素100毫克加10%葡萄糖液静滴治疗肠道感染,有3例发生此征,其中两例抢救无效死亡。用黄连素80～100毫克加10%葡萄糖液静滴治疗病毒性肝炎,有2例发生此征,另有2例出现心律紊乱——频发过早搏动,并伴有头昏、心慌及气急。动物实验证明,大量使用小蘖碱可使心搏停止,呼吸暂停,于死亡前出现抽搐现象。静脉给药可增加其毒性。②一例急性菌痢患者因肌注黄连 The author based on clinical data cited Coptis and berberine adverse reactions: ① acute cardiogenic cerebral ischemic syndrome: with berberine 100 mg plus 10% intravenous glucose solution for the treatment of intestinal infections, 3 cases of this sign, in which Two cases of invalid deaths. Treatment of viral hepatitis with berberine 80-100 mg plus 10% dextrose solution intravenously, 2 patients developed this syndrome, and another 2 patients had arrhythmia - frequent premature beats and dizziness, palpitation and urgency . Animal experiments show that a large number of berberine can make asystole, apnea, convulsions before death. Intravenous administration can increase its toxicity. ② cases of acute bacillary dysentery due to intramuscular injection of Coptis