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硝苯啶又名心痛定。各种不良后应亦日趋增多,发生率高达17～40％。而其它少见的不良反应也屡有报道,本文综述如下。 1 心血管系统 1.1 心绞痛:硝苯啶有明显的降压作用,使冠状动脉血流灌注减少,并伴有心率加快,心肌耗氧增加而引起心绞痛。赵以欣报道一男性患者,患高血压3年,服硝苯啶10mg,半小时左右即感心前区压榨性、窒息性疼痛,左肩不适,含服硝酸甘油0.6mg,疼痛消失。次日又服硝苯啶10mg,重现上述症状,经硝酸甘油治疗后缓解。 1.2 致心律失常:硝苯啶可诱发心律失常,机理不清。据朱仁贤报道1例心肌病、病态窦房结
Nifedipine also known as painkill. After all kinds of bad should also be increasing, the incidence as high as 17 to 40%. The other rare adverse reactions are also frequently reported, this article is summarized below. 1 cardiovascular system 1.1 angina pectoris: nifedipine has a significant antihypertensive effect, reducing coronary perfusion, accompanied by accelerated heart rate, increased myocardial oxygen consumption caused by angina. Zhao Yi Xin reported a male patient, suffering from hypertension for 3 years, taking nifedipine 10mg, half an hour or so that the front of the area of exasperation, asphyxia pain, left shoulder discomfort, containing nitroglycerin 0.6mg, pain disappeared. The next day and taking nifedipine 10mg, to reproduce the symptoms, remission after treatment with nitroglycerin. 1.2 induced arrhythmia: nifedipine can induce arrhythmia, the mechanism is unclear. According to a report of Zhu Renxian cardiomyopathy, sick sinus node